火狐体育

       隨著歐盟REACH的實施,其他國家也開始化學品的管理,如中國新化學物質申報、臺灣既有化學物質和新化學物質登錄、韓國K-REACH等等。排除比較特殊的聚合物注冊、中間體注冊等等,對于一個化學物質的常規注冊,所需要的數據測試費用少則幾萬、幾十萬元,多則數百萬元。為了動物福利以及為客戶節約時間、經濟成本,現行比較可行的方法有:QSAR、READ-ACROSS、體外測試方法,以及證據權重WOE方法。
  • QSAR

      dingxing(liang)gouxiaoguanxi,shishiyongshuxuemoxinglaimiaoshufenzijiegouhemouzhongshengwuhuoxingzhijiandeguanxi。zhezhongguanxi,tongchangyongyizhongsuanfajiangfenzijiegouhefenzideshengwuhuoxingguanlianqilai,biruxianxinghuigui、shenjingwangluo、zhichixiangliangji、yichuansuanfa、jueceshudengdeng。jiandandeshuo,jiushitongguoyixiejisuanjimoxinglaituicewuzhidemouxiexingzhihuozhehuoxing。

      zaishijiyingyongzhong,xuanzeheshide、yucexingnenghao、beiyanzhengguodemoxingquyuceweizhihuahewudemouzhongshengwuhuoxing,xiandeyouweiguanjian,qiebutongmoxinghuofangfahuodedeshengwuhuoxingjieguozhijiankeyixianghuyanzhengzuiweilixiang。dangranruguoninyongyouzugouduodeyangbenshuju(xunlianji),ninyekeshiyongxianyoudeyixieqsarruanjianjinxingjianmo、moxingyanzheng,ranhouyongyuweizhihuahewudeshengwuhuoxingdeyuce。

      xianjieduanchangyongdeqsarruanjianyouzhuruoecd toolbox、topkat、discovery studio、syble、acd/labs、multicase、epi suite、ecosardengdeng。

  • 物質分組(Grouping/Category )和交叉參照法(READ-ACROSS

      liyonglejiegouxiangjin、xingzhixiangsideyuanli,jiangmouxieyouyujiegouxiangsierzunxunmougeguizedewuzhi,guiweiyizu(group),huoyi“lei”(category)。tongguozaizuneicharuqitacankaowuzhi,liyong“zu”neigecankaowuzhidexianyoushuju,tongguojiaohucanzhaodefangshi(read-across),yuceqitawuzhiqueshidelihua、dulihuoshengtaidulixingzhi,congerbimianmeizhongwuzhidemeigexingzhijinxingceshidexuqiu,jieyueshujuchengben。

以上圖解為下圖所示。


  •  體外測試方法

changyongdeyouyanciji、pifucijihepifuzhimin。

pifuciji/fushiyou:oecd439、oecd430、oecd431heoecd435。

yancijiyou:oecd 437、oecd438heoecd460。

pifubiantaifanyingshiyan:oecd442c、oecd442d、h-clat。

tiwaiceshifangfazaibutongdefaguitixizhongderenkedubutong,rueu reachhezhongguoxinwuzhishenbaojiubutong,xuyaojutifenxi。

  • 證據權重(Weight of Evidence, WOE

      dangmouxiangcongmeigedulishujuyuandedaodeshujubeirenweibuzuyizhichimougeguandianshi,zecongruogangedulideshujuyuandedaodezonghezhengjukenengjuyouzugoudequanzhong,jiangduigaiwuzhiyoumouxiangteshudeweixiantexingzuochujiashehuojielun。

我們的服務:

(1)jianqsarmoxing,jinxingmubiaowuzhidelihua、duli、shengtaidulixingzhigusuan,bingzhuanxiezhuanyedeqmrfheqprfbaogao;

(2)yingyongshouguojirenkedeshangyeruanjiangusuanmubiaowuzhidemouxianglihua、dulihuoshengtaidulixingzhi,rutopkat 、acd/labs、discovery studiodengdeng,bingzhuanxiezhuanyedeqmrfheqprfbaogao;

(3)chayuequanweishujuku,liyongread acrosshuoshigroupingfangfa,tianbushujukongque;

(4)tiwaiceshifangfazixunguwen;

(5)liyongwoefazhuanxiepinggubaogao,yongyugexianglihua、duli、shengtaidulixingzhideyuce,jineryongyugeguohuaxuepinfaguizhucehuoshiqitarunongyao、huazhuangpinfaguidengfangmian。

我們的優勢:
  • 擁有專業的計算機模擬科研團隊,有教授、博士、碩士團隊;
  • 擁有數年的QSAR、READ-Across、WOE的化學品法規運用,如EU REACH、中國新物質申報的成功經驗,并獲專家評審委員會認可,成功率>90%;
  • 成功QSAR案例包括:理化性質如熔沸點、溶解度、正辛醇水分配系數、logKoc;健康毒理方面如ADME等的預測;生態毒理方面,如藻、溞、魚急性毒性、快速生物降解、生物富集,等等。還有通過其他非測試方法(如體外、WOE、READ-ACROSS等)豁免的許多理化、毒理、生態毒理數據成功案例。
 
聯系我們
服務熱線:4006-721-722
電話:0571-87206555
郵箱:Info@relatednews.net
活動信息
环球体育 火狐体育 环球体育 环球体育 英亚体育