火狐体育

“抗衰老神藥”NMN到底安不安全?企業需如何證實它的安全性?

jinjinian,nmnchengfenyinqi“kangshuailao”degongxiaoerbeigedashangjiazhuipeng,tongshinmnchengfenbaojianshipinguangshouxiaofeizhedexiai。aimeizixunshujuxianshi,2020nianzhongguonmnchengfenbaojianshipinshichangguimoda51.06yiyuan,tongbizengchang34.87%,yujidao2023nianjianghuiyijin70.25%dezengsupanshengzhi270.13yiyuan。suizhuwoguojingjidefazhanherenkoulaolinghuadexingshi,woguorenminduiyujiankangdeguanzhuduyuelaiyueda,er“yannianyishou”youshigeyonghengdezhuti,zhongxinzhengquangengshiyuce:woguonmnbaojianshipinweilaijuyouqianyishichangkongjian。qianyishichangshishenmegainian?woguobaojianshipinshichangguimobuguo4000yi。youcikeyikanchu,nmnchengfenbaojianshipinyibeiguangfanrenke。

那到底什么是NMN?它的抗衰老作用機理又是如何的?

nmnquanchengβ-yanxianandanhegansuan(yingwenming: β-nicotinamide mononucleotide),shirentineitianrancunzaidewuzhi,shixibaonengliangzhongyaolaiyuanzhiyi。nmnshiburudongwutineifumei i——yanxiananxianpiaolingerhegansuan(yingwenming: nicotinamide adenine dinucleotide,nad+)hechengdeguanjianqiantizhiyi,ernad+duirentijiankangyouzhuzhongyaozuoyong,canyushangqianzhongshengwucuihuafanying,qizonghanliangsuizhunianlingzengjiaerzhujianjianshao。dongwuyanjiubiaoming:koufunmnkeyitigaonad+deshuiping,keshiyurenleijiejindeshengwumoxingtixishoumingyanchang30%yishang。yincikezhi,nmnshitongguotishengnad+shuipingfahuikangshuailaogongneng。

NMN具體有哪些功效作用?

jinjinian,youguannmn shengwuxuegongnengdeyanjiuriyizengjia,tongguogexiangdongwuyanjiushiyanbiaoming,nmnjuyouyidingdexiangguangongxiao,zhuyaodegongnengmiaoshuruxia:

  • 抗衰老
  • 修復DNA損傷
  • 神經保護作用
  • 促進能量產生
  • 保護大腦健康:維持神經血管功能;改善阿茲海默癥;改善認知障礙等
  • 保護心臟健康
  • 糖尿病相關:調節胰島素分泌;保護胰島細胞功能
  • 體重控制
  • 改善暗視力和視網膜功能
  • 緩解急性腎損傷

lingwai,xiaofeizhezaifuyongnmnchengfenbaojianshipinhou,juedaduoshufankuipinglun “shuimianyouhendadegaishan、jingshenzhuangtaibianhao、pifuyuefaguangzejinzhideng” 。

NMN的安全性又如何呢?

nmndeyanhuanshuailaodegongxiaoxingsuiranxuyaojinyibudeyanzheng,youqihuanxuyaodaliangderentilinchuangshiyanlaizhengming,dantongguojinjiniandeshichangfankuihedongwumoxingyanjiuyijingchubushuomingnmnyugexianggongnengdexiangguanxing,jianjiezhengminglenmnyouyidingdekangshuailaozuoyong。chulegongnengxingzhiwai,nmnzuoweishipinyuanliao,zuijibendeanquanxingyoubaozhangma?guanyunmndeanquanxing,guoneiwaideguanfangpizhunqingkuangherentilinchuangyanjiuruxia:

首個人體臨床試驗研究:根據2020年日本慶應義塾大學醫學部Junichiro Irie等人發表的“Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men”,10名40-60歲的健康男性單次口服100mg、250mg 和500mg的NMN未引起任何明顯的臨床癥狀或副作用。

日本官方批準情況:根據日本厚生勞動省于2020年3月31日更新的「只要不標識藥品的功效效果,就不被判斷為藥品的成分(原料)清單」(非藥品成分清單)可知,只要不標識NMN的藥用效果,產品就不會被判斷為是藥品,加之日本不存在類似“食品可用原料清單”的正面清單。因此,可以證明NMN在日本可以用于食品生產銷售。

NMN,食品,原料,功效,安全

congyishangziliaokedechu,chulezairibenkeyihefashengchanxiaoshounmnshipinwai,muqianqitaguojiahediqudeguanfangjigourumeiguofda、oumengefsadengjunweipizhunnmnkeyizuoweishipinyuanliaohuobaojianshipinyuanliao(rugras notice, ndi, novel fooddeng)。baokuozaizhongguo,nmnzuoweixinshipinyuanliaoheshipintianjiajixinpinzhong,guojiaweijianwei(nhc)huanweiduiqijinxingguoanquanxingpinggugongzuo,gengmeiyoupizhunqikeyongyushipinhuobaojianshipinshengchanzhong。bingqie,guojiashichangjianguanzongju(samr)yeweipizhunguorenhenmmchengfenbaojianshipin。lingwai,keyizhengmingnmnanquanxingderentilinchuangyanjiuziliaoyeshaozhiyoushao。

yinci,henxianranzaizhongguo,nmnputongshipinhuobaojianshipinhuanbubeiyunxushengchanxiaoshou。weidutongguokuajingdianshangpingtai,zhongguoxiaofeizhecaikeyigoumaidaojinkoudenmnchanpin。dankuajingdianshangchanpindezhunrubingbushouzhongguoxingzhengguanlibumendejianguan,neinmnchanpindezhilianganquanshibicanchabuqi。zhegeshihou,jiuxuyaodianshangpingtaiheshangjiagongtongdanqizeren,jinxingziwoguifanlaiweihuxiaofeizhequanyiheshengminganquan,tongshiyekeyirangnmnkangshuailaochengfenzoudegengkexuegengyuan。huohutiyuyouyixiajigejianyigonggeweicankao:

如何來證明NMN的質量安全呢?

NMN原料角度:

nmnzuoweiyizhongxinshipinyuanliao,nmnshengchanqiyewanquankeyicankaoguojiaweijianweishenpixinshipinyuanliaodechengxu,ziwowanchengbiyaodeanquanpingguchengxu,ruyixiazhongyaohuanjie:

1

zhenduinmnyuanliaode,3picichengfenfenxiheweishengxuejiance(baokuonmnyuanliaochundu、ganguanceshi、zhongjinshuceshi、weishengwuceshideng)

2

zhenduinmnyuanliaode,1picidulixueshiyan(baokuojixingjingkouduxingshiyan、sanxiangyichuanduxingshiyan、90tianjingkouduxingshiyanhezhijishiyan)

3

weituozhongguoyouzizhidefengxianpinggujishujigouduinmnyuanliaojinxinganquanxingpinggu,bingchujuanquanxingpingguyijianbaogao

除此之外,在完成以上工作的基礎上,也可以考慮 ①委托美國專家對NMN原料進行安全評估工作,并簽發 “Self-Determined GRAS(GRAS 自我聲明)”證書。②嘗試向國家衛健委申請 “新食品原料”,并獲得行政批準。

NMN成分保健食品成品角度:

nmnchengfenbaojianshipinzuoweiyizhongzhongchanpin,zaizhongguochuletongguokuajingdianshangpingtaixiaoshouwai,zaiqitadexianshangxianxiapingtaixiaoshoudouxuyaoxiangguojiashichangjianguanzongjushenqinganquanpinggu,binghuodebaojianshipinzhucezhengshu。yinci,huohutiyujianyinmnchengfenbaojianshipinqiyecankaobaojianshipinzhuceyaoqiu,duichanpinjinxinganquanhegongxiaoshangdepinggu,jianyiwanchengyixiagongzuo:

1

zhenduinmnbaojianshipinde,cankaogb 16740-2014 shipinanquanguojiabiaozhun baojianshipin,jinxing3picigongxiaochengfenfenxiheweishengxuejiance(baokuonmnhanliang、ganguanceshi、zhongjinshuceshi、weishengwuceshideng)

2

zhenduinmnbaojianshipinde,3piciwendingxingshiyan

3

zhenduinmnbaojianshipinde,1picidulixueshiyan(baokuojixingjingkouduxingshiyan、sanxiangyichuanduxingshiyan、28tianjingkouduxingshiyan)

4

zhenduinmnbaojianshipinde,1picidongwugongnengshiyan

5

qitashiyan,ruxingfenjijiancedeng

zongshangsuoshu,jieheshichangfankui、dongwuyanjiuherentilinchuangyanjiudengjieguo,nmndegongxiaoxingheanquanxinghuanshijiaoweikekaode。jinguanruci,congqiyeshehuizerenhexiaofeizheshengminganquandejiaodukaolv,jianyiqiyewulunshiduinmnyuanliaohuanshinmnchengfendebaojianshipinyingdangwanchengziwoanquanpinggugongzuo。

火狐體育APP服務

  • NMN成分檢測,衛生學檢測(由天貓國際合作伙伴-浙江省檢驗檢疫科學技術研究院提供檢測方案)
  • 穩定性測試
  • 毒理試驗
  • 動物功能試驗
  • GRAS自我聲明
  • 衛健委新食品原料申請



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